Toxicity of the hydroalcoholic extract of the leaves of Cissus sicyoides

  • Gabriela Tafaela Dias Laboratório de Ensaios Toxicológicos do Instituto de Pesquisa em Fármacos e Medicamentos, Universidade Federal da Paraíba, João Pessoa, Brasil http://orcid.org/0000-0001-5885-172X
  • Caliandra Maria Bezerra Luna Lima Programa de Pós-Graduação em Modelos de Decisão e Saúde, Universidade Federal da Paraíba, João Pessoa, Brasil http://orcid.org/0000-0003-4281-139X
  • Andressa Brito Lira Programa de Pós-Graduação em Produtos Naturais e Bioativos Sintéticos, Universidade Federal da Paraíba, João Pessoa, Brasil http://orcid.org/0000-0003-4532-1986
  • Josue Amaral Ramalho Laboratório de Ensaios Toxicológicos do Instituto de Pesquisa em Fármacos e Medicamentos, Universidade Federal da Paraíba, João Pessoa, Brasil http://orcid.org/0000-0003-2065-7088
  • Kardilandia Mendes Oliveira Programa de Pós-Graduação em Desenvolvimento e Inovação Tecnológica, Universidade Federal da Paraíba, João Pessoa, Brasil http://orcid.org/0000-0003-4281-139X
  • Margareth Fátima Formiga Melo Diniz Programa de Pós Graduação em Fármaco e Medicamentos da Universidade de São Paulo, São Paulo, Brasil http://orcid.org/0000-0001-9896-9044

Abstract

Cissus sicyoides L. (cipó-anil, vegetal insulin) belongs to the family Vitacea. It is much used by the population for the treatment of diabetes. The objective of this research was to perform a phytochemical screening of the hydroalcoholic extract of leaves of C. sicyoides to be used as primary source in the toxicological test with Artemia salina L. Were be phytochemical tests on the hydroalcoholic extract of the leaves of C. sicyoides for research on secondary metabolites and was evaluated the toxicological activity using A. saline cysts to quantify the mean lethal concentration (CL50). The extract presented steroids, tannins, flavonoids and saponins, compounds that had already been found in other studies of this species. It presented high toxicity to A. salina, reporting a Mean Lethal Concentration (CL50) of 930.7 g mL-1, serving as a parameter for the accomplishment of later studies in animal models with the pretension to reach more results for a safe use of C. sicyoides.

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Published
2017-01-15
How to Cite
DIAS, Gabriela Tafaela et al. Toxicity of the hydroalcoholic extract of the leaves of Cissus sicyoides. Acta Brasiliensis, [S.l.], v. 1, n. 1, p. 8-12, jan. 2017. ISSN 2526-4338. Available at: <http://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/8>. Date accessed: 04 aug. 2020. doi: https://doi.org/10.22571/Actabra1120178.

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