Caracterização química e ação farmacológica da própolis vermelha brasileira
Abstract
Dentre os produtos naturais, a própolis brasileira destaca-se por ser considerada uma fonte para a descoberta de novos compostos bioativos. Na última década, foi descrita uma nova própolis brasileira, conhecida como própolis vermelha devido ao seu pigmento avermelhado. Desde então, inúmeras pesquisas revelando seus componentes majoritários e sua atividade farmacológica têm sido descritas. Dessa forma, esta pesquisa teve o objetivo de realizar uma revisão integrativa da literatura sobre a atividade biológica da própolis vermelha brasileira. Estudos científicos nos bancos de dados PubMed, SciELO e LILACS foram revisados e analisados utilizando-se uma abordagem indutiva e técnica de documentação indireta. Foram encontradas 418 publicações, sendo posteriormente aplicados critérios de inclusão e exclusão, selecionando ao todo 18 artigos. A própolis vermelha brasileira apresenta inúmeras propriedades farmacológicas, destacando-se os efeitos antibacteriano, antifúngico, antioxidante e anti-inflamatório. Além disso, a composição química desta substância é diferente dos demais tipos de própolis já relatados na literatura, apresentando flavonóides que ainda não tinham sido descritos. Dessa forma, suas características químicas sugerem provável uso terapêutico para o organismo humano.
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References
Alencar, S.M.; Oldoni, T.L.C.; Castro, M.L.; Cabral, I.S.R.; Costa-Neto, C.M.; Cury, J.A.; Rosalen, P.L.; Ikegaki, M. 2007. Chemical composition and biological activity of a new type of Brazilian propolis: red propolis, J. Ethnopharmacol, 113: 278-283.
Bueno-Silva, B.; Koo, H.; Falsetta, M.L.; Alencar, S.M.; Ikegaki, M.; Rosalen, P.L. 2013a. Effect of Neovestitol-vestitol containing Brazilian red propolis on biofilm accumulation in vitro and dental caries development in vivo. Biofouling, 29(10).
Bueno-Silva, B.; Franchin, M.; Alves, C.F.; Denny, C.; Colón, D.F.; Cunha, T.M.; Alencar, S.M.; Napimoga, M.H.; Rosalen, P.L. 2016. Main pathways of action of Brazilian red propolis on the modulation of neutrophils migration in the inflammatory process. Phytomedicine, 23:1583-1590.
Búfalo, M.C.; Candeias, J.M.G.; Sforcin, J.M. 2009. In vitro effect of Brazilian green propolis on human laryngeal epidermoid carcinoma (Hep-2) cells. Evid Based Complement Alternat Med, 6(4): 483-7.
Burdock, G.A. 1998. Review of the biological properties and toxicity of bee propolis. Food ChemToxicol, 36: 347-363.
Cabral, I.S.R.; Oldoni, T.L.C.; Prado, A.; Bezerra, R.M.N.; Alencar, S.M.; Kegaki, M.; Rosalen, P. L. 2009. Composição fenólica, atividade antibacteriana e antioxidante da própolis vermelha brasileira. Química Nova, 32(6): 1523-1527.
Camargo, R.A. 2005. A tribo Dalbergieae (Leguminosae -Faboideae) no estado de Santa Catarina, Brasil. Dissertação de Mestrado, Departamento de Botânica da Universidade Federal do Rio Grande do Sul/Rio Grande do Sul, Brasil. 153p.
Castaldo, S; Capasso, F. 2002. Propolis, an old remedy used in modern medicine. Fitoterapia, 1(1).
Cavendish, R.L.; Santos, J.S.; Belo Neto, R.; Paixão, A.O; Oliveira, V.J.; Araujo, E.D.; Silva, A.A.B.; Thomazzi, S.M.; Cardoso, J.C.; Gomes, M.Z. 2015. Antinociceptive and anti-inflammatory effects of Brazilian red propolis extract and formononetin in rodents. J. Ethnopharmacol., 173: 127-133.
Franchin, M.; Colón, D.F.; da Cunha, M.G.; Castanheira, F.V.; Saraiva, A.L.; Bueno-Silva, B.; Alencar, S.M.; Cunha, T.M.; Rosalen, P.L. 2016. Neovestitol, an isoflavonoid isolated from Brazilian red propolis, reduces acute and chronic inflammation: involvement of nitric oxide and IL-6. Sci Rep., 6(1).
Franchin, M.; Colón, D.F.; Castanheira, F.V; da Cunha, M.G.; Bueno-Silva, B.; Alencar, S.M.; Cunha, T.M.; Rosalen, P.L. 2016b. Vestitol Isolated from Brazilian Red Propolis Inhibits Neutrophils Migration in the Inflammatory Process: Elucidation of the Mechanism of Action. J Nat Prod. 79(4): 954-60.
Freires, I.A.; Alencar, S.M.; Rosalen, P.L. 2016. A pharmacological perspective on the use of Brazilian Red Propolis and its isolated compounds against human diseases. Eur J Med Chem, 110: 267-79.
Frozza, C.D.S., Garcia, C.S.C., Gambato, G., Souza, M.D., Salvador, M., Moura, S., Padilha, F.F., Seixas, F.K., Collares, T., Borsuk, S., Dellagostin, D.A., Henriques, J.A.P., & Roesch-Ely, M. 2013. Chemical characterization, antioxidant and cytotoxic activities of Brazilian red propolis. Food and Chemical Toxicology, 52: 137-142.
Gurnani, N.; Mehta, D.; Gupta, M.; Mehta, B.K. 2014. Natural Products: source of potential drugs. J. Basic Appl. Sci., 6(6): 171-186.
Kumazawa, S.; Ueda, R.; Hamasaka, T.; Fukumoto, S.; Fujimoto, T.; Nakayama, T. 2007. Antioxidant prenylated flavonoids from propolis collected in Okinawa, Japan. Journal of Agricultural and Food Chemistry, 55: 7722-7725.
Lee, C.H.; Yang, L.; Xu, J.Z.; Yeung, S.Y.V.; Huang, Y.; Chen, Z.Y. 2005. Relative antioxidant activity of soybean isoflavones and their glycosides. Food Chem., 90: 735-741.
Lima, H.C. 2012. Dalbergia em Lista de espécies da flora do Brasil.
López, B.G.; Schmidt, E.M.; Eberlin, M.N.; Sawaya, A.C. 2014. Phytochemical markers of different types of red propolis. Food Chem., 146: 174-80.
Lotti, C.; Campo Fernandez, M.; Piccinelli, A.L.; Cuesta-Rubio, D.; Márquez Hernández, I.; Rastrelli, L. 2010. Chemical constituents of red Mexican propolis. Journal of Agricultural and Food Chemistry, 58(4): 2209-2213.
Lustosa, S.R.; Galindo, A.B.; Nunes, L.C.C.; Randau, K.P.; Rolim Neto, P.J. 2008. Própolis: atualizações sobre a química e a farmacologia. RevBrasFarmacogn, 18: 447-454.
Machado, B.A.S.; Barreto, G.A.; Costa, A.S.; Costa, S.S.; Silva, R.P.D.; Silva, D.F.; Brandao, H.N.; Rocha, J.L.C.; Nunes, S.B.; Umsza-Guez, M.A.; Padilha, F.F. 2015. Determination of parameters for the supercritical extraction of antioxidant compounds from green propolis using carbon dioxide and ethanol as co-solvent. PLoS ONE, 10(8).
Machado, B.A.; Silva, R.P.; Barreto, G.D.E.A.; Costa, S.S.; Silva, D.F.; Brandão, H.N.; Rocha, J.L.; Dellagostin, O.A.; Henriques, J.A.; Umsza-Guez, M.A.; Padilha, F.F. 2016. Chemical Composition and Biological Activity of Extracts Obtained by Supercritical Extraction and Ethanolic Extraction of Brown, Green and Red Propolis Derived from Different Geographic Regions in Brazil. PLoS One, 1(1).
Marcucci, M.C. 1995. Propolis: chemical composition, biological properties and therapeutic activity. Apidologie, 26: 83-99.
Mendonça, L.S.; Mendonça, F.M.R.; Araújo, Y.L.F.M. Araújo, E.D.; Ramalho, S.A.; Narain, N.; Jain, S.; Drellana, S.C.; Padilha, F.F.; Cardoso, J.C. 2015. Chemical markers and antifungal activity of red propolis from Sergipe, Brazil. Food Sci. Technol, 35(2): 291-298.
Neves, M.V.;Silva, T.M.;Lima, E.O.;Cunha, E.V.;Oliveira, E.J. 2016. Isoflavone formononetin from red propolis acts as a fungicide against Candida sp. Braz J Microbiol., 47(1): 159-66.
Oldoni, T.L.C.; Oliveira, S.C.; Andolfatto, S.; Karling, M.; Calegari, M.A.; Sado, R.Y.; Maia, F.M.C.; Alencar, S.M.; Lima, V.A. 2015. Chemical Characterization and Optimization of the Extraction Process of Bioactive Compounds from Propolis Produced by Selected Bees Apis mellifera. J. Braz. Chem. Soc., 26(10).
Park, Y.K.; Ikegari, M.; Abreu, J.A.S.; Alcici, N.M.F. 1998. Estudo da preparação dos extratos de própolis e suas aplicações. Food Science and Technology, 18(3).
Park, Y.K.; Alencar, S.M.; Scamparine, A.R.P.; Aguiar, C.L. 2002. Própolis produzida no sul do Brasil, Argentina e Uruguai: Evidências fitoquímicas de sua origem vegetal. Ciência Rural, 2: 997-1003.
Pellati, F.; Epifano, F.; Contaldo, N.; Orlandini, G.; Cavicchi, L.; Genovese, S.; Bertelli, D.; Benvenuti, S.; Curini, M.; Bertaccini, A.; Bellardi, M.G.2011. Chromatographic methods for metabolite profiling of virus- and phytoplasma-infected plants of Echinacea purpurea. J. Agric. FoodChem, 59: 10425-10434.
Piccinelli, A.L.; Lotti, C.; Campone, L.; Cuesta-Rubio, O.; Campo Fernandez, M.; Rastrelli, L. 2011. Cuban and Brazilian red propolis: botanical origin and comparative analysis by highperformance liquid chromatography-photodiode array detection/electrospray ionization tandem mass spectrometry. J Agric Food Chem, 59(12): 6484-91.
Pippi, B.; Lana, A.J.; Moraes, R.C.; Güez, C.M.; Machado, M.; de Oliveira, L,F,; Lino von Poser, G.; Fuentefria, A.M. 2015. In vitro evaluation of the acquisition of resistance, antifungal activity and synergism of Brazilian red propolis with antifungal drugs on Candida sp. J Appl Microbiol., 118 (4): 839-50.
Trusheva, B.; Popova, M.; Bankova, V.; Simova, S.; Marcucci, M.C.; Miorin, P.L.; Pasin, F.R.; Tsvetkova, I. 2006. Bioactive constituents of Brazilian red propolis. eCAM, 3:249-254.
Salatino, A.; Teixeira, E.W.; Negri, G.; Message, D. 2005. Origin and Chemical Variation of Brazilian Propolis. Evidence-Based Compl. Altern. Med, 2: 33-8.
Silva, B.B.; Rosalen, P.L.; Cury, J.A.; Ikegaki, M.; Souza, V.C.; Esteves, A. Alencar, S.M. 2008. Chemical composition and botanical origin of red propolis, a new type of Brazilian propolis. Evid Based Complement Alternat Med., 5(3): 313-316.
Sforcin, J.M.; Fernandes, J.r.A.; Lopes, C.A.M.; Bankova, V.; Funari, S.R.C. 2000. Seasonal effect on Brazilian própolis antibacterial activity. J Ethnopharmacol, 73: 243-249.
Regueira Neto, M.S.; Tintino, S.R.; Silva, A.R.P.; Costa, M.S.; Boligon, A.A.; Matias, E.F.F.; Balbinoa, V.Q.; Menezes, I.R.A.; Coutinho, H.D.M. 2017. Seasonal variation of Brazilian red propolis: Antibacterial activity, synergistic effect and phytochemical screening. Food and Chemical Toxicology, 107: 572-580.
Righi, A.A.; Alves, T.R.; Negri, G.; Marques, L.M.; Breyer, H.; Salatino, A. 2011. Brazilian red propolis: unreported substances, antioxidant and antimicrobial activities. J Sci Food Agric., 91(13): 2363-70.
Siqueira, A.B.; Gomes, B.S.; Cambuim, I.; Maia, R.; Abreu, S.; Souza-Motta, C.M.; Queiroz, L.A.; Porto, A.L. 2009. Trichophyton species susceptibility to green and red propolis from Brazil. Lett Appl Microbiol., 48(1).
Tiveron, A.P.; Rosalen, P.L.; Ranchin, M.; Lacerda, R.C.C.; Bueno-Silva, B.; Benso, B.; Denny, C.; Ikegari, M.; Alencar, S.M. 2016. Chemical Characterization and Antioxidant, Antimicrobial, and Anti-Inflammatory Activities of South Brazilian Organic Propolis. PLoS One, 11(11).
Van Boeckel, T.P.; Gandra, S.; Ashok, A.; Caudron, Q.; Levin, S.A. 2014. Laxminarayan R. Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data. Lancet Infect Dis, 14: 742-50.
Wagh, V.D. 2013. Propolis: a wonder bees product and its pharmacological potentials. Adv Pharm Sci, (1).
World Health Organization. 2014. Antimicrobial Resistance: Global Report on Surveillance. World Health Organization, Geneva, Switzerland. 257p.
Xavier, T.F.; Kannan, M.; Auxilia, A. 2015. Observation on the traditional phytotherapy among the Malayali tribes in Eastern Ghats of Tamil Nadu, South India. J. Ethnopharmacol., 165(1).
Xie, X.L.; Gi, M.; Fujioka, M.; Doi, K.; Yamano, S.; Tachibana, H.et al. 2015. Ethanol-extracted propolis enhances BBN-initiated urinary bladder carcinogenesis via non-mutagenic mechanisms in rats. Food ChemToxicol, 83: 193-200.
Yixi, X.; Yang, W.; Tang, F.; Chen, X.; Ren, L. 2015. Antibacterial Activities of Flavonoids: Structure-Activity Relationship and Mechanism. Current Medicinal Chemistry, 22: 132-149.
Bueno-Silva, B.; Koo, H.; Falsetta, M.L.; Alencar, S.M.; Ikegaki, M.; Rosalen, P.L. 2013a. Effect of Neovestitol-vestitol containing Brazilian red propolis on biofilm accumulation in vitro and dental caries development in vivo. Biofouling, 29(10).
Bueno-Silva, B.; Franchin, M.; Alves, C.F.; Denny, C.; Colón, D.F.; Cunha, T.M.; Alencar, S.M.; Napimoga, M.H.; Rosalen, P.L. 2016. Main pathways of action of Brazilian red propolis on the modulation of neutrophils migration in the inflammatory process. Phytomedicine, 23:1583-1590.
Búfalo, M.C.; Candeias, J.M.G.; Sforcin, J.M. 2009. In vitro effect of Brazilian green propolis on human laryngeal epidermoid carcinoma (Hep-2) cells. Evid Based Complement Alternat Med, 6(4): 483-7.
Burdock, G.A. 1998. Review of the biological properties and toxicity of bee propolis. Food ChemToxicol, 36: 347-363.
Cabral, I.S.R.; Oldoni, T.L.C.; Prado, A.; Bezerra, R.M.N.; Alencar, S.M.; Kegaki, M.; Rosalen, P. L. 2009. Composição fenólica, atividade antibacteriana e antioxidante da própolis vermelha brasileira. Química Nova, 32(6): 1523-1527.
Camargo, R.A. 2005. A tribo Dalbergieae (Leguminosae -Faboideae) no estado de Santa Catarina, Brasil. Dissertação de Mestrado, Departamento de Botânica da Universidade Federal do Rio Grande do Sul/Rio Grande do Sul, Brasil. 153p.
Castaldo, S; Capasso, F. 2002. Propolis, an old remedy used in modern medicine. Fitoterapia, 1(1).
Cavendish, R.L.; Santos, J.S.; Belo Neto, R.; Paixão, A.O; Oliveira, V.J.; Araujo, E.D.; Silva, A.A.B.; Thomazzi, S.M.; Cardoso, J.C.; Gomes, M.Z. 2015. Antinociceptive and anti-inflammatory effects of Brazilian red propolis extract and formononetin in rodents. J. Ethnopharmacol., 173: 127-133.
Franchin, M.; Colón, D.F.; da Cunha, M.G.; Castanheira, F.V.; Saraiva, A.L.; Bueno-Silva, B.; Alencar, S.M.; Cunha, T.M.; Rosalen, P.L. 2016. Neovestitol, an isoflavonoid isolated from Brazilian red propolis, reduces acute and chronic inflammation: involvement of nitric oxide and IL-6. Sci Rep., 6(1).
Franchin, M.; Colón, D.F.; Castanheira, F.V; da Cunha, M.G.; Bueno-Silva, B.; Alencar, S.M.; Cunha, T.M.; Rosalen, P.L. 2016b. Vestitol Isolated from Brazilian Red Propolis Inhibits Neutrophils Migration in the Inflammatory Process: Elucidation of the Mechanism of Action. J Nat Prod. 79(4): 954-60.
Freires, I.A.; Alencar, S.M.; Rosalen, P.L. 2016. A pharmacological perspective on the use of Brazilian Red Propolis and its isolated compounds against human diseases. Eur J Med Chem, 110: 267-79.
Frozza, C.D.S., Garcia, C.S.C., Gambato, G., Souza, M.D., Salvador, M., Moura, S., Padilha, F.F., Seixas, F.K., Collares, T., Borsuk, S., Dellagostin, D.A., Henriques, J.A.P., & Roesch-Ely, M. 2013. Chemical characterization, antioxidant and cytotoxic activities of Brazilian red propolis. Food and Chemical Toxicology, 52: 137-142.
Gurnani, N.; Mehta, D.; Gupta, M.; Mehta, B.K. 2014. Natural Products: source of potential drugs. J. Basic Appl. Sci., 6(6): 171-186.
Kumazawa, S.; Ueda, R.; Hamasaka, T.; Fukumoto, S.; Fujimoto, T.; Nakayama, T. 2007. Antioxidant prenylated flavonoids from propolis collected in Okinawa, Japan. Journal of Agricultural and Food Chemistry, 55: 7722-7725.
Lee, C.H.; Yang, L.; Xu, J.Z.; Yeung, S.Y.V.; Huang, Y.; Chen, Z.Y. 2005. Relative antioxidant activity of soybean isoflavones and their glycosides. Food Chem., 90: 735-741.
Lima, H.C. 2012. Dalbergia em Lista de espécies da flora do Brasil.
López, B.G.; Schmidt, E.M.; Eberlin, M.N.; Sawaya, A.C. 2014. Phytochemical markers of different types of red propolis. Food Chem., 146: 174-80.
Lotti, C.; Campo Fernandez, M.; Piccinelli, A.L.; Cuesta-Rubio, D.; Márquez Hernández, I.; Rastrelli, L. 2010. Chemical constituents of red Mexican propolis. Journal of Agricultural and Food Chemistry, 58(4): 2209-2213.
Lustosa, S.R.; Galindo, A.B.; Nunes, L.C.C.; Randau, K.P.; Rolim Neto, P.J. 2008. Própolis: atualizações sobre a química e a farmacologia. RevBrasFarmacogn, 18: 447-454.
Machado, B.A.S.; Barreto, G.A.; Costa, A.S.; Costa, S.S.; Silva, R.P.D.; Silva, D.F.; Brandao, H.N.; Rocha, J.L.C.; Nunes, S.B.; Umsza-Guez, M.A.; Padilha, F.F. 2015. Determination of parameters for the supercritical extraction of antioxidant compounds from green propolis using carbon dioxide and ethanol as co-solvent. PLoS ONE, 10(8).
Machado, B.A.; Silva, R.P.; Barreto, G.D.E.A.; Costa, S.S.; Silva, D.F.; Brandão, H.N.; Rocha, J.L.; Dellagostin, O.A.; Henriques, J.A.; Umsza-Guez, M.A.; Padilha, F.F. 2016. Chemical Composition and Biological Activity of Extracts Obtained by Supercritical Extraction and Ethanolic Extraction of Brown, Green and Red Propolis Derived from Different Geographic Regions in Brazil. PLoS One, 1(1).
Marcucci, M.C. 1995. Propolis: chemical composition, biological properties and therapeutic activity. Apidologie, 26: 83-99.
Mendonça, L.S.; Mendonça, F.M.R.; Araújo, Y.L.F.M. Araújo, E.D.; Ramalho, S.A.; Narain, N.; Jain, S.; Drellana, S.C.; Padilha, F.F.; Cardoso, J.C. 2015. Chemical markers and antifungal activity of red propolis from Sergipe, Brazil. Food Sci. Technol, 35(2): 291-298.
Neves, M.V.;Silva, T.M.;Lima, E.O.;Cunha, E.V.;Oliveira, E.J. 2016. Isoflavone formononetin from red propolis acts as a fungicide against Candida sp. Braz J Microbiol., 47(1): 159-66.
Oldoni, T.L.C.; Oliveira, S.C.; Andolfatto, S.; Karling, M.; Calegari, M.A.; Sado, R.Y.; Maia, F.M.C.; Alencar, S.M.; Lima, V.A. 2015. Chemical Characterization and Optimization of the Extraction Process of Bioactive Compounds from Propolis Produced by Selected Bees Apis mellifera. J. Braz. Chem. Soc., 26(10).
Park, Y.K.; Ikegari, M.; Abreu, J.A.S.; Alcici, N.M.F. 1998. Estudo da preparação dos extratos de própolis e suas aplicações. Food Science and Technology, 18(3).
Park, Y.K.; Alencar, S.M.; Scamparine, A.R.P.; Aguiar, C.L. 2002. Própolis produzida no sul do Brasil, Argentina e Uruguai: Evidências fitoquímicas de sua origem vegetal. Ciência Rural, 2: 997-1003.
Pellati, F.; Epifano, F.; Contaldo, N.; Orlandini, G.; Cavicchi, L.; Genovese, S.; Bertelli, D.; Benvenuti, S.; Curini, M.; Bertaccini, A.; Bellardi, M.G.2011. Chromatographic methods for metabolite profiling of virus- and phytoplasma-infected plants of Echinacea purpurea. J. Agric. FoodChem, 59: 10425-10434.
Piccinelli, A.L.; Lotti, C.; Campone, L.; Cuesta-Rubio, O.; Campo Fernandez, M.; Rastrelli, L. 2011. Cuban and Brazilian red propolis: botanical origin and comparative analysis by highperformance liquid chromatography-photodiode array detection/electrospray ionization tandem mass spectrometry. J Agric Food Chem, 59(12): 6484-91.
Pippi, B.; Lana, A.J.; Moraes, R.C.; Güez, C.M.; Machado, M.; de Oliveira, L,F,; Lino von Poser, G.; Fuentefria, A.M. 2015. In vitro evaluation of the acquisition of resistance, antifungal activity and synergism of Brazilian red propolis with antifungal drugs on Candida sp. J Appl Microbiol., 118 (4): 839-50.
Trusheva, B.; Popova, M.; Bankova, V.; Simova, S.; Marcucci, M.C.; Miorin, P.L.; Pasin, F.R.; Tsvetkova, I. 2006. Bioactive constituents of Brazilian red propolis. eCAM, 3:249-254.
Salatino, A.; Teixeira, E.W.; Negri, G.; Message, D. 2005. Origin and Chemical Variation of Brazilian Propolis. Evidence-Based Compl. Altern. Med, 2: 33-8.
Silva, B.B.; Rosalen, P.L.; Cury, J.A.; Ikegaki, M.; Souza, V.C.; Esteves, A. Alencar, S.M. 2008. Chemical composition and botanical origin of red propolis, a new type of Brazilian propolis. Evid Based Complement Alternat Med., 5(3): 313-316.
Sforcin, J.M.; Fernandes, J.r.A.; Lopes, C.A.M.; Bankova, V.; Funari, S.R.C. 2000. Seasonal effect on Brazilian própolis antibacterial activity. J Ethnopharmacol, 73: 243-249.
Regueira Neto, M.S.; Tintino, S.R.; Silva, A.R.P.; Costa, M.S.; Boligon, A.A.; Matias, E.F.F.; Balbinoa, V.Q.; Menezes, I.R.A.; Coutinho, H.D.M. 2017. Seasonal variation of Brazilian red propolis: Antibacterial activity, synergistic effect and phytochemical screening. Food and Chemical Toxicology, 107: 572-580.
Righi, A.A.; Alves, T.R.; Negri, G.; Marques, L.M.; Breyer, H.; Salatino, A. 2011. Brazilian red propolis: unreported substances, antioxidant and antimicrobial activities. J Sci Food Agric., 91(13): 2363-70.
Siqueira, A.B.; Gomes, B.S.; Cambuim, I.; Maia, R.; Abreu, S.; Souza-Motta, C.M.; Queiroz, L.A.; Porto, A.L. 2009. Trichophyton species susceptibility to green and red propolis from Brazil. Lett Appl Microbiol., 48(1).
Tiveron, A.P.; Rosalen, P.L.; Ranchin, M.; Lacerda, R.C.C.; Bueno-Silva, B.; Benso, B.; Denny, C.; Ikegari, M.; Alencar, S.M. 2016. Chemical Characterization and Antioxidant, Antimicrobial, and Anti-Inflammatory Activities of South Brazilian Organic Propolis. PLoS One, 11(11).
Van Boeckel, T.P.; Gandra, S.; Ashok, A.; Caudron, Q.; Levin, S.A. 2014. Laxminarayan R. Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data. Lancet Infect Dis, 14: 742-50.
Wagh, V.D. 2013. Propolis: a wonder bees product and its pharmacological potentials. Adv Pharm Sci, (1).
World Health Organization. 2014. Antimicrobial Resistance: Global Report on Surveillance. World Health Organization, Geneva, Switzerland. 257p.
Xavier, T.F.; Kannan, M.; Auxilia, A. 2015. Observation on the traditional phytotherapy among the Malayali tribes in Eastern Ghats of Tamil Nadu, South India. J. Ethnopharmacol., 165(1).
Xie, X.L.; Gi, M.; Fujioka, M.; Doi, K.; Yamano, S.; Tachibana, H.et al. 2015. Ethanol-extracted propolis enhances BBN-initiated urinary bladder carcinogenesis via non-mutagenic mechanisms in rats. Food ChemToxicol, 83: 193-200.
Yixi, X.; Yang, W.; Tang, F.; Chen, X.; Ren, L. 2015. Antibacterial Activities of Flavonoids: Structure-Activity Relationship and Mechanism. Current Medicinal Chemistry, 22: 132-149.
Published
2018-01-20
How to Cite
CAVALCANTI DE PONTES, Marcela Lins et al.
Caracterização química e ação farmacológica da própolis vermelha brasileira.
Acta Brasiliensis, [S.l.], v. 2, n. 1, p. 34-39, jan. 2018.
ISSN 2526-4338.
Available at: <http://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/68>. Date accessed: 26 apr. 2024.
doi: https://doi.org/10.22571/2526-433868.
Section
Review
